PSF
•Scientific concept•
The
term "Protein Structure Factory" was chosen to represent a common
initiative of the German Human Genome Project (DHGP) and structural biologists
from the Berlin area aimed at the broad-scale analysis of proteins.
The Protein Structure Factory is established to characterize proteins
encoded by the genes or cDNAs available at the Berlin Resource Center
of DHGP. At a later stage, it may analyze various sets of input proteins
selected by criteria of potential structural novelty or medical or biotechnological
usefulness. It represents an integrative approach to structure analysis
combining the computer-based analysis of genes by bioinformatics techniques,
automated gene expression and purification of gene products, generation
of a biophysical fingerprint of the proteins and the determination of
their three-dimensional structures either in solution by NMR spectroscopy
or in the crystalline state by X-ray diffraction.
Linking structural biology with genome research: The Berlin "Protein Structure Factory" initiative
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© 2003 PSF, last changed 15 Mar 2004